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Updated: Jun 27, 2025

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DDX21: The link between m6A and R-loops.

Guillaume Lavergne1, Jean-Yves Roignant2

  • 1Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.

Molecular Cell
|May 3, 2024
PubMed
Summary

The RNA helicase DDX21 guides the m6A methyltransferase complex to R-loops. This recruitment is crucial for correct transcription termination and maintaining genome stability.

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