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Opioids and Accelerated Brain Aging: The White Matter Matters

Robert J Pignolo1

  • 1Divisions of Hospital Internal Medicine and Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine; Section on Geriatric Medicine and Gerontology; and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings
|May 3, 2024
PubMed
Summary

No abstract available in PubMed .

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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