Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

585
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
585
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

422
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
422

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ozanimod and other sphingosine-1-phosphate receptor 1 modulators normalize neuropathic injury-enhanced inhibition of central lateral amygdala neurons expressing corticotropin-releasing hormone.

Neuropharmacology·2026
Same author

Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model.

bioRxiv : the preprint server for biology·2026
Same author

Novel dimeric dual-modality FAP-targeted agents with favorable tumor retention for image-guided surgery: a preclinical study.

European journal of nuclear medicine and molecular imaging·2025
Same author

Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.

The Journal of biological chemistry·2025
Same author

Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer.

Molecular therapy. Nucleic acids·2025
Same author

Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation.

iScience·2025
Same journal

Decoding the oncogenic functions and translational potential of Twinfilin-1.

The Journal of pharmacology and experimental therapeutics·2026
Same journal

Antiproliferative effects of HIV integrase strand transfer inhibitors in experimental models for cancer research: A narrative review.

The Journal of pharmacology and experimental therapeutics·2026
Same journal

Modulation of morphine tolerance and dependence by pyrroloquinoline quinone in mice: Insights into mechanistic bridge from N-methyl-D-aspartate receptors-calcium/calmodulin-dependent protein kinase II signaling to oxidative neuroinflammation.

The Journal of pharmacology and experimental therapeutics·2026
Same journal

Improving drug delivery to mitigate cisplatin nephrotoxicity.

The Journal of pharmacology and experimental therapeutics·2026
Same journal

Sublethal stress from polypharmacy modulates scavenging function and fenestrations in mouse liver sinusoidal endothelial cells.

The Journal of pharmacology and experimental therapeutics·2026
Same journal

Purmorphamine mitigates 3-nitropropionic acid-induced neurodegeneration via enhancing the brain-derived neurotrophic factor/protein kinase B/glycogen synthase kinase-3β signaling and attenuation of oxidative/nitrosative stress, neuroinflammation, and apoptosis.

The Journal of pharmacology and experimental therapeutics·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.2K

Targeting Prefrontal Cortex Dysfunction in Pain.

Kai Kummer1, Patrick L Sheets2

  • 1Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria (K.K.); Department of Pharmacology and Toxicology (P.L.S.), Medical Neurosciences Graduate Program (P.L.S.), and Stark Neurosciences Research Institute (P.L.S.), Indiana University School of Medicine, Indianapolis, Indiana.

The Journal of Pharmacology and Experimental Therapeutics
|May 3, 2024
PubMed
Summary
This summary is machine-generated.

Chronic pain disrupts the prefrontal cortex (PFC), impacting mood and cognition. Targeting PFC offers new therapeutic strategies for chronic pain and its associated conditions.

More Related Videos

Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

262.6K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K

Related Experiment Videos

Last Updated: Jun 27, 2025

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.2K
Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

262.6K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K

Area of Science:

  • Neuroscience
  • Pain Research
  • Psychiatry

Background:

  • The prefrontal cortex (PFC) is increasingly recognized for its role in chronic pain.
  • Decades of research in rodents and humans support studying PFC dysfunction in chronic pain.
  • Chronic pain leads to structural, chemical, and connectivity changes in the PFC.

Purpose of the Study:

  • To review the complex changes in rodent and human PFC due to chronic pain.
  • To explore potential pharmacological and non-pharmacological treatments targeting the PFC.
  • To highlight the PFC's role in pain-induced comorbidities like anxiety, depression, and cognitive decline.

Main Methods:

  • Comprehensive literature review of rodent and human studies on PFC and chronic pain.
  • Synthesis of findings on structural, chemical, and connectivity alterations in the PFC.
  • Analysis of existing and potential therapeutic interventions targeting PFC circuits.

Main Results:

  • Chronic pain significantly alters PFC structure, chemistry, and connectivity in both species.
  • PFC dysfunction is implicated in the persistence of chronic pain and its comorbidities.
  • Evidence suggests PFC manipulation can alleviate pain and associated psychological distress.

Conclusions:

  • The PFC is a critical target for novel chronic pain therapies.
  • Targeting PFC circuits offers a promising avenue for developing safer and more effective pain treatments.
  • Understanding PFC's role is key to addressing the unmet need for better chronic pain management and comorbidity treatment.