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Updated: Jun 27, 2025

Orienteering as a Tool for Cognitive Research: An Implementation Guide
Published on: November 29, 2024
Does the liver facilitate aging-related cognitive impairment: Conversation between liver and brain during exercise?
Changling Wei1, Xue Li1, Yu Jin1
1School of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, China.
Abstract:
Liver, an important regulator of metabolic homeostasis, is critical for healthy brain function. In particular, age-related neurodegenerative diseases seriously reduce the quality of life for the elderly. As population aging progresses rapidly, unraveling the mechanisms that effectively delay aging has become critical. Appropriate exercise is reported to improve aging-related cognitive impairment. Whereas current studies focused on exploring the effect of exercise on the aging brain itself, ignoring the persistent effects of peripheral organs on the brain through the blood circulation. The aim of this paper is to summarize the communication and aging processes of the liver and brain and to emphasize the metabolic mechanisms of the liver-brain axis about exercise ameliorating aging-related neurodegenerative diseases. A comprehensive understanding of the potential mechanisms about exercise ameliorating aging is critical for improving adaptation to age-related brain changes and formulating effective interventions against age-related cognitive decline.
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