Potency of a small molecule that targets the molluscum contagiosum virus processivity factor increases when
Hancheng Guan1, Manunya Nuth1, Richard W Scott2
1Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.
Abstract:
We recently developed compound FC-7269 for targeting the Molluscum contagiosum virus processivity factor (mD4) and demonstrated its ability to inhibit viral processive DNA synthesis in vitro and cellular infection of an mD4-dependent virus (Antiviral Res 211, 2023,105520). However, despite a thorough medicinal chemistry campaign we were unable to generate a potent second analog as a requisite for drug development. We overcame this impasse, by conjugating a short hydrophobic trivaline peptide to FC-7269 to produce FC-TriVal-7269 which significantly increased antiviral potency and reduced cellular toxicity.
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