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Therapeutic Interventions for Diabetes Mellitus-associated Complications
Dharmendra Pradhan1, Prafulla Kumar Sahu1, Sukumar Purohit1
1School of Pharmacy, Centurion University of Technology and Management, Odisha, India.
Current Diabetes Reviews
|May 6, 2024
Summary
This review summarizes advancements in understanding and treating diabetes mellitus (DM), a global health crisis. It covers complications, natural product therapies, and novel treatments like stem cell therapy for better patient outcomes.
Area of Science:
- Endocrinology and Metabolism
- Pharmacology and Therapeutics
Background:
- Diabetes Mellitus (DM) affects over 537 million globally, posing significant morbidity and mortality risks.
- Understanding DM's complex pathophysiology and progression is crucial for effective management.
Purpose of the Study:
- To review the pathogenesis of hyperglycemia and its complications.
- To consolidate current and emerging optimal treatment strategies for DM.
Main Methods:
- Traditional literature review of the past two decades.
- Searched prominent databases (PubMed, Scopus, Google Scholar, Web of Science, ClinicalTrials.gov) using keywords like 'diabetes,' 'complications,' and 'novel therapies.'
Main Results:
- Discussed macrovascular (atherosclerosis, CVD, PAD, stroke) and microvascular (nephropathy, retinopathy, neuropathy) complications.
- Highlighted pharmacological, non-pharmacological, and natural product interventions targeting metabolic pathways and oxidative stress.
- Explored novel therapies including genetic, stem cell, and immunomodulatory approaches, alongside precision medicine.
Conclusions:
- An improved understanding of DM advancements is vital for clinicians.
- This knowledge enhances the identification of the most effective therapeutic interventions for patients.
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