Related Experiment Video

Updated: May 7, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.0K

Puerperal mastitis caused by limited community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)

Yu-Cheng Lin1, Yu-Lin Lee2,3, Yi-Hsin Chen4,5,6

  • 1Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.

Frontiers in Medicine
|May 6, 2024
PubMed
Abstract

Insights

A study identified specific community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones causing puerperal mastitis. Implementing an infection control bundle significantly reduced mastitis and CA-MRSA mastitis incidence.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Microbiology

Background:

  • Puerperal mastitis is a postpartum infection.
  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant public health threat.
  • Understanding MRSA epidemiology in postpartum women is crucial for effective control.

Purpose of the Study:

  • To investigate the epidemiology of MRSA puerperal mastitis.
  • To evaluate the impact of an infection control bundle on MRSA mastitis rates.

Main Methods:

  • MRSA isolates from mastitis cases and hospital environment were characterized using MLST, SCCmec, spa, agr typing, and PFGE.
  • Phenotypic analyses included toxin profiling and vancomycin MIC determination.
  • Mastitis incidence was compared before and after implementing an infection control bundle.

Main Results:

  • A specific MRSA clone (ST59-SCCmecVT-spa t437-agr group I, pvl-positive) was identified in clinical and environmental samples.
  • Clonal relatedness was observed between clinical mastitis cases and colonized staff/environmental sources.
  • Post-intervention, mastitis incidence decreased from 13.01 to 1.78 per 100 deliveries, and MRSA mastitis incidence decreased from 3.70 to 0.99 per 100 deliveries.

Conclusions:

  • Distinct CA-MRSA clones were implicated in puerperal mastitis outbreaks.
  • A targeted infection control bundle effectively controlled the MRSA mastitis outbreak.
Keywords:
CA-MRSAMLSTPFGESCCmecinfection control bundlepuerperal mastitis

More Related Videos

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

11.9K
Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR08:51

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR

Published on: November 4, 2016

9.6K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...