Advancing cell-based therapy in sepsis: An anesthesia outlook

Area of Science:

• Immunology
• Regenerative Medicine
• Critical Care Medicine

Background:

• Sepsis is a global health challenge with high mortality, and current treatments like bundle therapy have limitations.
• Existing approaches, including organ support and signaling pathway trials, have not effectively reversed multiple organ failure in sepsis.
• There is an urgent need for innovative therapies to address organ injuries in surgical patients with sepsis.

Purpose of the Study:

• To review the current status and advancements in immune cell therapy for sepsis.
• To discuss the potential of stem cell-based interventions and CAR-immune cell therapy in sepsis management.
• To explore strategies for perioperative sepsis management using cell-based approaches.

Main Methods:

• Review of current literature on cell therapy in sepsis.
• Analysis of advancements in single-cell sequencing and gene-editing technologies.
• Discussion of immune cell interactions and modulation in sepsis pathogenesis.

Main Results:

• Cell therapy, especially stem cell-based interventions, is a promising avenue for repairing organ damage and restoring homeostasis.
• Immune cell modulation is central to sepsis pathogenesis, making immune cell therapies relevant.
• CAR-immune cell therapy presents an intriguing option for sepsis treatment.

Conclusions:

• Cell therapy offers a novel approach to treating sepsis by targeting immune responses and organ repair.
• Advancements in technology are enhancing our understanding and application of immune cell therapies for sepsis.
• Further research into cell-based strategies is crucial for improving perioperative sepsis management.