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Review of Current Tuberculosis Human Infection Studies for Use in Accelerating Tuberculosis Vaccine Development: A
Shobana Balasingam1, Keertan Dheda2, Sarah Fortune3
1Infectious Disease, Wellcome Trust, London, United Kingdom.
The Journal of Infectious Diseases
|May 6, 2024
Summary
Validated human infection studies are crucial for accelerating tuberculosis (TB) vaccine development. Addressing challenges in model validity and safety is key to advancing global TB control strategies.
Area of Science:
- Vaccinology
- Infectious Diseases
- Clinical Trials
Background:
- Accelerating tuberculosis (TB) vaccine development requires robust evaluation tools.
- Human infection studies offer a promising avenue for understanding TB pathogenesis and identifying correlates of protection.
- Existing challenges hinder the full clinical utility of TB human infection models.
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