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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
EMM-Promoted Pd-Catalyzed Solid State Intramolecular Heck-Type Cyclization/Boronation and Suzuki Couplings: Access to
Yuwei Jia1, Hui Wang1, Jintao Guo1
1School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, People's Republic of China.
Abstract:
EMM (electromagnetic mill)-promoted Pd-catalyzed solid state intramolecular Heck-type cyclization/boronation and Suzuki couplings are reported. Compared to previous mechanochemistry that constructed one chemical bond through a cross-coupling reaction, this strategy realizes cascade transformation along with multiple chemical bond formation. This conversion does not require organic solvents or additional heating, and it shows a good substrate scope and high functional group tolerance.
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