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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
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Related Experiment Video

Updated: Jun 27, 2025

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Published on: June 21, 2024

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Acupuncture Point Selection Patterns for Chemotherapy-Induced Nausea and Vomiting: A Data Mining Analysis.

Zi Ke1, Hongruyu Chen2, Yong Zhao3

  • 1Department of Integrated Chinese and Western Medicine, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, katzinkezi@outlook.com.

Complementary Medicine Research
|May 6, 2024
PubMed
Summary

This study identified optimal acupuncture point combinations for chemotherapy-induced nausea and vomiting (CINV). The combination of CV4, CV12, ST36, CV6, and PC6 offers an evidence-based approach to manage CINV symptoms.

Keywords:
AcupointsAcupunctureAkupunkturAkupunkturpunkteChemotherapie-induzierte Übelkeit und ErbrechenChemotherapy-induced nausea and vomitingData MiningData miningTraditional Chinese medicineTraditionelle chinesische Medizin

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Area of Science:

  • Integrative Oncology
  • Traditional Chinese Medicine
  • Clinical Research

Background:

  • Chemotherapy-induced nausea and vomiting (CINV) significantly impairs cancer patient quality of life and treatment adherence.
  • Identifying effective acupuncture strategies is crucial for managing CINV.

Purpose of the Study:

  • To determine optimal acupoint selection patterns for CINV.
  • To explore treatment principles for effective acupoint combinations in CINV management.

Main Methods:

  • Systematic review of 104 clinical trials.
  • Descriptive statistics, association rule mining, network analysis, and cluster analysis using R software.

Main Results:

  • 48 acupoints were identified, with ST36, PC6, and CV12 being most frequent.
  • The Stomach, Conception Vessel, and Pericardium meridians were commonly selected.
  • The optimal acupoint combination for CINV was identified as CV4, CV12, ST36, CV6, and PC6, aligning with the principle of "harmonizing the stomach, stopping vomiting, and descending counterflow."

Conclusions:

  • This research provides an evidence-based acupuncture prescription for treating CINV.
  • The findings offer a complementary therapy for physicians and patients to manage CINV.