Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

44.4K
Overview
44.4K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

776
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
776
Development of Immunocompetence01:22

Development of Immunocompetence

303
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
303
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How the Immune System Learns.

PRX life·2026
Same author

Active RNA synthesis patterns nuclear condensates.

Cell systems·2026
Same author

Genetically homogeneous sector morphologies emerge from anisotropic colony growth.

Physical review. E·2026
Same author

Minimal model of self-organized clusters with phase transitions in ecological communities.

Physical review. E·2026
Same author

A unifying model of LAT condensates in reconstitution experiments.

bioRxiv : the preprint server for biology·2025
Same author

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV.

Cell reports·2025
Same journal

Poisoning the Genome: Targeted Backdoor Attacks on DNA Foundation Models.

ArXiv·2026
Same journal

Mechanistic mathematical model of the in vitro infection dynamics of Bunyamwera and Batai viruses including MOI-dependent shortening of the eclipse phase.

ArXiv·2026
Same journal

AI-Driven Lumped-Element Modeling of Human Respiratory System for Studying Voice Mechanics.

ArXiv·2026
Same journal

Beyond Algorithms: Conceptual Innovation in Medical Imaging AI.

ArXiv·2026
Same journal

Feynman Kac Reweighted Schrödinger Bridge Matching for Surface-Based Tau PET Harmonization.

ArXiv·2026
Same journal

Agentic Discovery of Non-Canonical Antimicrobial Peptides with AMPGAN v3.

ArXiv·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.7K

A Minimal Framework for Optimizing Vaccination Protocols Targeting Highly Mutable Pathogens.

Saeed Mahdisoltani, Pranav Murugan, Arup K Chakraborty

    Arxiv
    |May 7, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Optimizing vaccine protocols can enhance the generation of broadly neutralizing antibodies (bnAbs) against mutable pathogens like HIV and influenza. This study models B cell evolution to guide vaccine-induced selection forces for improved antibody responses.

    More Related Videos

    Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
    22:10

    Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

    Published on: June 28, 2013

    13.3K
    Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
    07:44

    Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

    Published on: May 12, 2023

    1.2K

    Related Experiment Videos

    Last Updated: Jun 27, 2025

    Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
    08:52

    Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

    Published on: February 22, 2019

    10.7K
    Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
    22:10

    Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

    Published on: June 28, 2013

    13.3K
    Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
    07:44

    Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

    Published on: May 12, 2023

    1.2K

    Area of Science:

    • Immunology
    • Computational Biology
    • Vaccine Development

    Background:

    • Highly mutable pathogens like HIV and influenza pose significant public health challenges due to difficulties in developing effective immunization strategies.
    • B cell affinity maturation, a Darwinian evolutionary process, is crucial for generating high-affinity antibodies during immunization.

    Conclusions:

    • The study provides a theoretical framework for designing vaccination protocols to improve bnAb generation.
    • Optimized selection forces can enhance the effectiveness of vaccines against rapidly evolving viruses.
    • The findings contribute to the development of more robust immunization strategies for challenging pathogens.