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Related Experiment Video

Updated: Jun 27, 2025

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Divergent Subregional Information Processing in Mouse Prefrontal Cortex During Working Memory.

Alex Sonneborn¹, Lowell Bartlett¹, Randall J Olson¹

¹Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR.

Biorxiv : the Preprint Server for Biology

|May 7, 2024

Summary

This summary is machine-generated.

Working memory relies on coordinated brain activity. Different medial prefrontal cortex subregions specialize in distinct phases of working memory, revealing segregated neural computations.

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Last Updated: Jun 27, 2025

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Published on: February 26, 2012

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A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

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Published on: July 16, 2015

Area of Science:

Neuroscience
Cognitive Neuroscience
Systems Neuroscience

Background:

Working memory (WM) is crucial for guiding actions using recent information.
Prefrontal cortex (PFC) subregions coordinate for WM, but their functional specialization across WM phases in freely-moving animals remains unclear.
Electrophysiological recordings in mice are needed to understand dynamic neural activity in WM.

Approach:

Recorded single-unit activity in three medial PFC (mPFC) subregions (MOs, dmPFC, vmPFC) of mice during a non-match-to-position WM task.
Analyzed neural activity patterns across different phases of the working memory task.
Investigated functional specialization and information coding within mPFC subregions.

Key Points:

Supplementary motor area (MOs) showed peak activity at task transitions and selective encoding of sample location.
Dorsomedial PFC (dmPFC) exhibited stable, persistent neural codes specific to sample location during the delay period.
Ventromedial PFC (vmPFC) responded most strongly to reward information during the choice phase.

Conclusions:

Demonstrated anatomically and temporally segregated processing of WM information within the mPFC.
Highlighted distinct roles of MOs, dmPFC, and vmPFC in different stages of working memory.
Emphasized the need for precise consideration of dynamic neural activity in WM computations.