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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Optociliary shunt vessels in multiple sclerosis.

Sana Nadeem1, Aasma Nudrat Zafar2

  • 1Department of Ophthalmology, Foundation University Medical College and Fauji Foundation Hospital, Rawalpindi, Pakistan.

The International Journal of Neuroscience
|May 7, 2024
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Summary
This summary is machine-generated.

Optic neuritis, often seen in multiple sclerosis, may cause optociliary shunt vessels due to retinal hypoperfusion. This study highlights this previously unreported link in two patients with multiple sclerosis.

Keywords:
Optociliary shunt vesselsmultiple sclerosisneuroretinitisoptic neuritisretinochoroidal veinsvisual field lossvisual loss

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Area of Science:

  • Ophthalmology
  • Neurology
  • Vascular Biology

Background:

  • Optociliary shunt vessels typically arise from chronic retinal venous obstruction.
  • Optic neuritis has not been previously identified as a cause of optociliary shunts.

Purpose of the Study:

  • To investigate if optic neuritis is a risk factor for developing optociliary shunts in multiple sclerosis patients.
  • To establish a potential link between demyelinating optic neuritis and optociliary shunt formation.

Main Methods:

  • A case series of two patients diagnosed with multiple sclerosis.
  • Clinical evaluation including visual field testing, optical coherence tomography (OCT), and OCT angiography.
  • Neuroimaging to confirm demyelination.

Main Results:

  • Two female patients with multiple sclerosis developed optociliary shunt vessels following optic neuritis episodes.
  • Both patients exhibited signs of retinal thinning, ganglion cell complex loss, and reduced capillary density.
  • Visual field defects and retinal/optic nerve edema were observed.

Conclusions:

  • Demyelinating optic neuritis in multiple sclerosis may lead to chronic retinal hypoperfusion.
  • This hypoperfusion can subsequently cause the development of optociliary shunt vessels.
  • This case series suggests optic neuritis as a potential, previously unreported cause of optociliary shunts.