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Updated: Jun 27, 2025

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Inherent directing group-enabled Co(III)-catalyzed C-H allylation/vinylation of isoquinolones
Sachin1,2, Tamanna Sharma1, Devesh Chandra1
1C-H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur 176061, India. upendraihbt@gmail.com.
Abstract:
Co(III)-catalysed site-selective C8-allylation and vinylation of isoquinolones with allyl acetate and vinyl acetates has been accomplished. The oxo group of isoquinolone has been utilised as an inherent directing group. Based on preliminary mechanistic studies, a plausible mechanism for the developed reaction has also been delineated. Broad substrate scope with good to excellent yields and post-synthetic transformations of allylated and vinylated isoquinolines highlight the importance of the reaction.
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