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Decoding cardiovascular risks: analyzing type 2 diabetes mellitus and ASCVD gene expression.

Youqi Zhang1,2, Liu Ji1,2, Daiwei Yang3

  • 1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

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Summary
This summary is machine-generated.

Atherosclerotic cardiovascular disease (ASCVD) is a major cause of death in type 2 diabetes mellitus (T2DM). This study identifies ABCC5 and WDR7 genes and potential therapies for both conditions.

Keywords:
GEO databaseNHANES databaseWGCNAatherosclerosistype 2 diabetes mellitus

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Area of Science:

  • Genetics and Genomics
  • Metabolic Diseases
  • Cardiovascular Health

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality in individuals with type 2 diabetes mellitus (T2DM).
  • A potential link between ASCVD and T2DM necessitates further investigation into shared molecular mechanisms.

Purpose of the Study:

  • To analyze the interrelation between ASCVD and T2DM using large-scale datasets.
  • To identify shared genetic factors and molecular pathways implicated in both conditions.
  • To discover potential therapeutic agents targeting both T2DM and ASCVD.

Main Methods:

  • Utilized linear and multivariate logistic regression, Wilcoxon test, and Spearman's correlation on NHANES data (2001-2018).
  • Employed Gene Expression Omnibus (GEO) and Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression networks.
  • Applied LASSO regression for hub gene identification, followed by bioinformatics analyses (GO, KEGG) and small molecule prediction.

Main Results:

  • Abnormal lipid metabolism, influenced by blood glucose, is critical in ASCVD development among diabetic patients.
  • Identified ABCC5 and WDR7 as pivotal genes associated with both T2DM and ASCVD.
  • Enrichment analyses revealed intertwined lipid metabolism pathways and immune involvement in both diseases.

Conclusions:

  • ABCC5 and WDR7 are identified as novel target genes linking T2DM and ASCVD.
  • RITA, ON-01910, doxercalciferol, and topiramate show promise as potential therapeutic agents for both conditions.