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Published on: April 18, 2019
Practical synthesis of isoindolines yields potent colistin potentiators for multidrug-resistant Acinetobacter
Somnath Dutta1, Samantha Eyolfson1, Yuhang Zhu1
1Department of Chemistry, University of Colorado Boulder, Boulder, 80309, USA. xiang.wang@colorado.edu.
Abstract:
An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing an isoindole umpolung strategy. A variety of isoindolines were prepared with good to excellent yields. Biological screens of these identified compounds demonstrated that they are potent potentiators of colistin for multi-drug resistant Acinetobacter baumannii.
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