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The role of the ER stress sensor IRE1 in cardiovascular diseases

Lu Zhou1, Xizi Zhu1, Shaoqing Lei1

  • 1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

Molecular and Cellular Biochemistry
|May 8, 2024
PubMed

Insights

Inositol-requiring enzyme 1 (IRE1) plays a key role in cardiovascular diseases beyond the unfolded protein response. Targeting IRE1 offers potential therapeutic strategies for heart failure and I/R injury.

Area of Science:

  • Cardiovascular Biology
  • Endoplasmic Reticulum Stress
  • Unfolded Protein Response

Background:

  • Cardiovascular diseases remain a leading cause of global mortality.
  • Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum sensor managing cellular stress.
  • Persistent endoplasmic reticulum stress activates unfolded protein response pathways, leading to cell death.

Purpose of the Study:

  • To summarize recent findings on IRE1's role in cardiovascular diseases.
  • To discuss the therapeutic potential of targeting IRE1 for cardiovascular conditions.

Main Methods:

  • Literature review of recent research on IRE1 and cardiovascular diseases.
  • Analysis of IRE1's involvement in inflammation, immunity, and lipid metabolism.

Main Results:

  • IRE1 regulates inflammation, immunity, and lipid metabolism in cardiovascular disease progression.
  • IRE1's functions extend beyond its role in the unfolded protein response.

Conclusions:

  • IRE1 is a significant factor in cardiovascular disease pathogenesis.
  • Modulating IRE1 activity presents a promising therapeutic avenue for treating cardiovascular diseases like I/R injury and heart failure.

Keywords:
Cardiovascular diseasesEndoplasmic reticulum stressInositol-requiring enzyme 1Unfolded protein responseXBP1

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