Surface-functionalised polymeric nanoparticles for breast cancer treatment: processes and advances

Area of Science:

• Oncology
• Materials Science
• Nanotechnology

Background:

• Cancer is the second leading cause of death globally, driving pharmaceutical focus on anticancer products.
• Effective drug delivery to tumor sites is crucial for cancer treatment, necessitating novel therapeutic strategies.
• Nanotechnology provides tools for developing advanced nano delivery systems with controlled and targeted drug release.

Purpose of the Study:

• To review processes and advances in surface functionalization of nanoparticles for breast cancer treatment.
• To explore therapeutic molecules, polymers, and preparation techniques for anticancer nanoparticles.
• To focus on nanoparticle functionalization strategies for targeting diverse breast cancer types.

Main Methods:

• Review of scientific literature on nanoparticle fabrication and functionalization techniques.
• Analysis of polymers used in nanoparticle formulation for drug delivery.
• Examination of surface modification methods for targeted nanoparticle delivery.

Main Results:

• Nanoparticles can be fabricated using scalable and economic polymer-based techniques.
• Surface functionalization allows for specific tissue targeting and versatile drug release profiles.
• Various ligands can be introduced to functionalize nanoparticles for different breast cancer subtypes.

Conclusions:

• Surface-functionalized nanoparticles represent a promising approach for targeted breast cancer therapy.
• Nanotechnology enables the development of sophisticated drug delivery systems with enhanced therapeutic potential.
• Further research into nanoparticle functionalization can optimize breast cancer treatment outcomes.