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Updated: Jun 26, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses
Qiang Cai1, Yihao Tian2, Quazi T H Shubhra3
1Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Abstract:
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase's crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
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