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Central auditory function in Alzheimer's disease.

A M Grimes, C L Grady, N L Foster

    Neurology
    |March 1, 1985
    PubMed
    Summary
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    Alzheimer's disease significantly impairs central auditory (dichotic) function. This impairment relates to intelligence, temporal lobe atrophy, and glucose metabolism, suggesting specific neurological links.

    Area of Science:

    • Neuroscience
    • Auditory Neuroscience
    • Cognitive Neurology

    Background:

    • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
    • Central auditory processing deficits are increasingly recognized in AD.
    • Dichotic listening tasks assess the brain's ability to process auditory information from both ears.

    Purpose of the Study:

    • To investigate central auditory (dichotic) function in Alzheimer's disease patients.
    • To explore relationships between dichotic performance and cognitive/neurological factors in AD.
    • To examine the influence of temporal lobe structure and metabolism on dichotic listening.

    Main Methods:

    • Compared dichotic listening performance in 38 Alzheimer's disease patients and a control group.
    • Assessed correlations between dichotic scores, intelligence quotient (IQ), and temporal lobe cortical atrophy.

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  • Measured cerebral glucose metabolism in the temporal lobes using neuroimaging techniques.

    • Main Results:

    • Significant impairment in dichotic function was observed in Alzheimer's disease patients.
    • Dichotic scores correlated significantly with IQ, left temporal lobe glucose metabolism, and temporal lobe atrophy.
    • Contralateral ear effects and interactions between atrophy asymmetry and dichotic performance were noted.

    Conclusions:

    • Central auditory processing is significantly affected in Alzheimer's disease.
    • Dichotic listening deficits are linked to cognitive decline and specific temporal lobe pathologies in AD.
    • Findings support models of dichotic listening involving temporal lobe function and asymmetry.