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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Role of Bilastine in Allergic Rhinitis: A Narrative Review.

Mangesh Tiwaskar1, Agam Vora2, Kamlesh Tewary3

  • 1Consultant Physician and Diabetologist, Shilpa Medical Research Centre, Mumbai, Maharashtra, India, Corresponding Author.

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Allergic rhinitis (AR) is often underestimated but can lead to asthma. Bilastine, a non-sedating H1 antihistamine, offers effective and safe treatment for AR with minimal side effects and drug interactions.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Otolaryngology

Background:

  • Allergic rhinitis (AR) is frequently self-treated, despite being a risk factor for asthma and other complications.
  • Inflammation in AR is primarily histamine-mediated, necessitating effective antihistamine treatment.
  • Current guidelines recommend second-generation H1 antihistamines for AR management due to their safety profile.

Purpose of the Study:

  • To review current guidelines for allergic rhinitis (AR) management.
  • To comprehensively discuss the role and efficacy of bilastine in treating AR.
  • To highlight bilastine's pharmacokinetic profile and safety in diverse patient populations.

Main Methods:

  • Narrative review of existing literature and clinical guidelines on allergic rhinitis.
  • Analysis of bilastine's pharmacological properties, including receptor specificity and pharmacokinetics.
  • Evaluation of bilastine's safety, tolerability, and drug interaction profile.

Main Results:

  • Bilastine demonstrates high specificity for H1 receptors with minimal affinity for others.
  • It offers rapid, prolonged action, improving patient compliance and reducing dosing frequency.
  • Bilastine is well-tolerated long-term, non-sedating, and has a low potential for drug interactions, making it suitable for elderly patients.

Conclusions:

  • Bilastine is a safe and effective second-generation H1 antihistamine for allergic rhinitis (AR).
  • Its favorable pharmacokinetic profile and minimal adverse effects support its use across various patient groups, including the elderly.
  • Bilastine represents a valuable therapeutic option in the management of AR according to current guidelines.