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A transaminase-mediated aldol reaction and applications in cascades to styryl pyridines

Yu Wang1, Yiwen Li2, Yeke Ni1

  • 1Department of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.

Catalysis Science & Technology
|May 9, 2024
PubMed

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The Knoevenagel condensation is an aldol-type reaction involving the condensation of aldehydes or ketones with active methylene compounds such as β-diesters to produce substituted olefins.
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The aldol reaction of a ketone under acidic conditions successfully forms an unsaturated carbonyl as the final product instead of an aldol. The acid-catalyzed aldol reaction is depicted in Figure 1.
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