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Ribosome Assembly and Repair.

Yoon-Mo Yang1,2, Katrin Karbstein3,2

  • 1Current affiliation: Graduate School of Biomedical Science and Engineering and Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Republic of Korea;

Annual Review of Cell and Developmental Biology
|May 9, 2024
PubMed
Summary
This summary is machine-generated.

Cells can repair damaged ribosomes, a vital process for protein homeostasis. This ribosome repair mechanism saves energy compared to synthesizing new ones, especially during cellular stress.

Keywords:
ribosomal protein chaperoneribosomal protein turnoverribosome assemblyribosome damageribosome repairribosome turnover

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Ribosomes are essential for protein synthesis and cellular function.
  • Maintaining ribosome integrity is crucial for protein homeostasis.
  • Existing quality control primarily addresses assembly errors, not lifelong damage.

Purpose of the Study:

  • To review known types of ribosome damage.
  • To survey established ribosome repair mechanisms.
  • To explore potential additional instances of ribosome repair.

Main Methods:

  • Literature review of ribosome damage.
  • Analysis of ribosome repair pathways.
  • Survey of scientific literature for repair evidence.

Main Results:

  • Ribosomes can be repaired by removing damaged proteins.
  • Ribosome repair is energetically efficient compared to de novo synthesis.
  • This repair is particularly relevant under stress conditions.

Conclusions:

  • Ribosome repair contributes to maintaining cellular function and protein homeostasis.
  • Repair mechanisms offer an energy-saving alternative to ribosome biogenesis.
  • Further investigation into additional repair instances is warranted.