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Epstein-Barr Virus-Associated Smooth-Muscle Tumor of the Brain
Afra Alfalahi1,2, Abdelsimar Il Omar3,4, Krystal Fox3
1From the Division of Diagnostic Neuroradiology (A.A., A.B., S.S.), St. Michael's Hospital-Unity Health Toronto, University of Toronto, Toronto, Ontario, Canada.
None:
Epstein-Barr virus, a herpesvirus, has been associated with a variety of cancers, including Burkitt, Hodgkin, and non-Hodgkin lymphomas; posttransplant lymphoproliferative disorders; gastric carcinoma; and nasopharyngeal carcinoma, in both immunocompetent and immunocompromised individuals. Previous studies have established a connection between Epstein-Barr virus and the development of smooth-muscle tumors. Smooth-muscle tumors of the brain are very rare and are often misdiagnosed as meningiomas on imaging. To our knowledge, advanced imaging findings such as MR perfusion of smooth-muscle tumors of the brain have never been reported. We describe the radiologic and pathologic features of the Epstein-Barr virus-associated smooth-muscle tumors of the brain in a person with newly diagnosed advanced HIV.
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