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Updated: Jun 26, 2025
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A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
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The cellular composition of chronic subdural hematoma
Thorbjørn Søren Rønn Jensen1, Markus Harboe Olsen2,3, Christina Christoffersen4
1Department of Neurosurgery, The Neuroscience Centre, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen, Rigshospitalet, Denmark. tjens07@gmail.com.
Acta Neurochirurgica
|May 9, 2024
Summary
Chronic subdural hematoma (CSDH) fluid contains different cell compositions than systemic blood, with higher MCV in recurrent cases. This suggests inflammation plays a role in CSDH development and recurrence.
Area of Science:
- Neuroscience
- Hematology
- Immunology
Background:
- The exact mechanisms driving chronic subdural hematoma (CSDH) formation and recurrence are not fully understood.
- Investigating the cellular makeup of CSDH fluid may illuminate these complex pathological processes.
- This research is the first to analyze cellular composition in both systemic blood and CSDH fluid.
Purpose of the Study:
- To compare the cellular composition of CSDH fluid with systemic blood.
- To identify cellular differences between patients with and without CSDH recurrence.
- To examine cellular variations between initial and subsequent surgeries for recurrent CSDH.
Main Methods:
- Collected systemic blood and CSDH fluid from patients undergoing primary and secondary surgeries for CSDH.
- Analyzed cell counts (white blood cells, erythroblasts, platelets, etc.) and cellular indices (MCV, MCH, MCHC).
- Included parameters like hemoglobin and hematocrit in the analysis.
Main Results:
- CSDH fluid exhibited a distinct cellular composition compared to systemic blood (p < 0.0001).
- Higher mean corpuscular volume (MCV) in CSDH fluid from the primary operation predicted recurrence (p = 0.009).
- Inflammatory cell distribution in CSDH fluid differed between the first and second operations in recurrent cases (p = 0.0017).
Conclusions:
- This study pioneers the analysis of CSDH fluid's cellular composition.
- Elevated immune cell presence in CSDH fluid supports an inflammatory role in CSDH pathophysiology.
- Increased MCV in subdural fluid during the first operation is linked to subsequent CSDH recurrence.
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