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Guidelines for ketamine use in clinical psychiatry practice
Luke A Jelen1, Rupert McShane2, Allan H Young3
1The Maudsley Hospital, London, UK; and Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Bjpsych Open
|May 10, 2024
Summary
Ketamine shows promise for treatment-resistant depression but requires clear guidelines for safe use. National registries are advocated to monitor therapy and ensure effective depression management.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Ketamine is increasingly recognized for its efficacy in treating treatment-resistant depression (TRD).
- However, its clinical use presents significant challenges regarding administration and monitoring.
Purpose of the Study:
- To emphasize the efficacy and challenges of ketamine for TRD.
- To highlight the necessity of evidence-based guidelines for managing ketamine formulations (both licensed and off-label).
- To discuss current efforts in developing ketamine guidelines and advocate for national registries.
Main Methods:
- This editorial reviews current literature and discusses recent developments in ketamine therapy for depression.
- It examines the need for comprehensive management strategies and monitoring systems.
Main Results:
- The editorial underscores the dual nature of ketamine: high efficacy coupled with management challenges.
- It notes the ongoing development of guidelines, such as those by Beaglehole et al. in New Zealand.
Conclusions:
- Comprehensive, evidence-based guidelines are crucial for the safe and effective use of ketamine in depression.
- National registries are essential for monitoring ketamine therapy and ensuring optimal patient outcomes.
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