Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.5K
Assessment of the Abdomen III: Palpation01:23

Assessment of the Abdomen III: Palpation

559
Palpation is a crucial tactile examination method for assessing abdominal organs and detecting conditions like tenderness, distention, masses, or fluid. It involves both light and deep palpation techniques, each serving specific diagnostic purposes. Light palpation helps identify tenderness and other surface-level indicators, while deep palpation locates and assess abdominal masses and organ boundaries. A skilled professional can gather valuable insights through palpation, including evaluating...
559
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

920
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
920
Tissue Transplantation01:24

Tissue Transplantation

360
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
360

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When acute leukemias trick us: A case of T-lymphoid/myeloid mixed phenotype acute leukemia.

Annales de biologie clinique·2026
Same author

A rare chain of events: Post-follicular therapy-related t(8;21) acute myeloid leukaemia with KIT D816Y mutation revealing systemic mastocytosis.

British journal of haematology·2026
Same author

Platelet-Mimicking RBC Microfragments: PLT-F Interference on Sysmex XN Analyzers in Pediatrics.

International journal of laboratory hematology·2026
Same author

The shape-shifting plasma cell: Multiple myeloma with CKS1B amplification.

British journal of haematology·2026
Same author

Therapy-Related Acute Myeloid Leukaemia Arising in a Patient With Relapsed Follicular Lymphoma.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same author

Now You See Me, Now You Don't: A Case of A Diffuse Large B Cell Lymphoma With A Leukemic Phase.

International journal of laboratory hematology·2026
Same journal

[The role of the heart-on-a-chip to drug evaluation].

Annales de biologie clinique·2026
Same journal

A morphology-driven proof-of-concept study linking interphase nuclear abnormalities to dicentric-mediated genomic instability.

Annales de biologie clinique·2026
Same journal

Analytical validation and clinical concordance of Diazyme free light chain assays on the Cobas® platform compared with Freelite™.

Annales de biologie clinique·2026
Same journal

Small-cell secondary plasma cell leukemia mimicking low-grade B-cell lymphoma.

Annales de biologie clinique·2026
Same journal

[Multiple myeloma and analytical discrepancy in serum free light chain assay: a case report].

Annales de biologie clinique·2026
Same journal

[Summary of the 34th National Conference of the National College of Hospital Biochemistry].

Annales de biologie clinique·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2025

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

15.8K

[An expanding spleen].

Anastasia Milojkovic, Anne-Margaux Dejean, Marianne Tarnat

    Annales De Biologie Clinique
    |May 10, 2024
    PubMed
    Summary
    This summary is machine-generated.

    A young woman presented with persistent epistaxis, anemia, and thrombopenia, indicating significant blood count abnormalities. Further investigation via myelogram was conducted to determine the underlying cause of these hematological issues.

    Keywords:
    cytopeniasmyelogramsplenomegaly

    More Related Videos

    Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
    04:40

    Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

    Published on: November 4, 2022

    1.1K
    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
    07:30

    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

    Published on: June 28, 2024

    1.4K

    Related Experiment Videos

    Last Updated: Jun 26, 2025

    A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
    08:04

    A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

    Published on: June 11, 2019

    15.8K
    Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
    04:40

    Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

    Published on: November 4, 2022

    1.1K
    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
    07:30

    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

    Published on: June 28, 2024

    1.4K

    Area of Science:

    • Hematology
    • Internal Medicine
    • Clinical Diagnostics

    Background:

    • Persistent epistaxis can be a symptom of underlying hematological disorders.
    • Bi-cytopenias, specifically anemia and thrombopenia, suggest bone marrow dysfunction or peripheral destruction.
    • Splenomegaly is often associated with hematological abnormalities and can impact blood cell counts.

    Observation:

    • A 24-year-old female patient presented with intractable epistaxis.
    • Biological evaluation revealed bi-cytopenias, characterized by anemia and thrombopenia.
    • Clinical examination showed significant splenomegaly (fourth grade).

    Findings:

    • The patient's presentation suggested a potential bone marrow disorder or a condition affecting multiple blood cell lineages.
    • The combination of epistaxis, bi-cytopenias, and splenomegaly warranted a detailed examination of the bone marrow.
    • A myelogram was performed to investigate the etiology of the observed hematological abnormalities.

    Implications:

    • Diagnostic procedures like myelogram are crucial for identifying the cause of complex cytopenias.
    • Understanding the interplay between epistaxis, cytopenias, and splenomegaly aids in differential diagnosis.
    • Early and accurate diagnosis is essential for timely and effective management of hematological conditions.