Easy access to polyhalogenated biaryls: regioselective (di)halogenation of hypervalent bromines and chlorines
Daniel Carter Martos1, Maxime de Abreu1, Pascal Hauk1
1Laboratoire d'Innovation Moléculaire et Applications (LIMA, UMR CNRS 7042), Université de Strasbourg/Université de Haute Alsace, ECPM 67087 Strasbourg France wenceldelord@unistra.fr.
Abstract:
Polyhalogenated biaryls are unique motifs offering untapped potential as versatile building blocks for the expedient synthesis of complex biaryl compounds. Overcoming the limitations of conventional syntheses, we introduce a novel, metal-free, operationally simple and one-pot approach to regioselectively (di)halogenate biaryl compounds under mild conditions using cyclic biaryl hypervalent bromine and chlorine substrates as masked arynes. Through chemoselective post-functionalizations, these valuable products can expand the toolbox for synthesizing biaryl-containing scaffolds, addressing a critical gap in the field.
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