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Updated: Jun 26, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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SSH3 promotes pancreatic cancer proliferation and migration by activating the notch signaling pathway

Chengxiao Yang1, Gang Quan1, Shihang Zhang1

  • 1Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital) Dongguan, Guangdong, China.

American Journal of Cancer Research
|May 10, 2024
PubMed

Insights

Dual-specificity phosphatases (DUSP) are implicated in pancreatic cancer (PC) progression. SSH3, a key gene, promotes PC cell growth and migration via Notch signaling, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The dual-specificity phosphatases (DUSP) family's role in pancreatic cancer (PC) progression is under investigation.
  • Identifying novel therapeutic targets is critical for improving PC treatment outcomes.

Purpose of the Study:

  • To explore the DUSP family's involvement in pancreatic cancer development.
  • To identify and validate key genes and develop a prognostic risk model for PC patients.
  • To investigate potential therapeutic strategies, including immune and chemical drug targets.

Main Methods:

  • Multivariate Cox proportional hazards analysis identified differentially expressed genes.
  • A novel risk model was developed and validated for PC prognosis.
  • Tumor immune analysis and potential chemical drug predictions were performed.
  • SSH3 expression levels, correlation with clinical parameters, and functional roles were assessed.

Main Results:

  • A subset of 20 differentially expressed genes was identified, highlighting DUSP10, PTP4A2, SSH3, and CDKN3.
  • A validated risk model for PC prognosis was established.
  • Elevated SSH3 expression was observed in PC cells and tissues, correlating with grade, staging, and T stage.
  • SSH3 enhances PC cell proliferation and migration through Notch signaling pathway activation.

Conclusions:

  • SSH3 is a significant factor in pancreatic cancer progression, linked to tumor severity and patient outcomes.
  • SSH3's role in promoting proliferation and migration via Notch signaling presents a potential therapeutic target for pancreatic cancer.
  • The developed risk model and identified genes offer valuable prognostic information for PC patients.
Keywords:
DUSP familySlingshot protein phosphatase 3TCGApancreatic cancerprognostic prediction

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