Stereoselective synthesis of an advanced trans-decalin intermediate towards the total synthesis of anthracimycin
Laksamee Jeanmard1, Giacomo Lodovici1, Ian George1
1Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. ian.fairlamb@york.ac.uk.
Abstract:
Progress towards the total synthesis of the macrolide natural product anthracimycin is described. This new approach utilises an intermolecular Diels-Alder strategy followed by epimeirsation to form the key trans-decalin framework. The route culminates in the stereoselective synthesis of an advanced tricyclic lactone intermediate, containing five contiguous sterogenic centres with the correct relative and absolute stereochemistry required for the anthracimycin core motif.
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