Breast Cancer Immune Landscape: Interplay Between Systemic and Local Immunity

Area of Science:

• Immunology
• Oncology
• Cancer Research

Background:

• Breast cancer (BC) is a leading global malignancy in women.
• The immune system plays a critical role in cancer development and progression.
• Tumor-immune system interactions are complex, with tumors capable of evading immune surveillance.

Purpose of the Study:

• To provide a comprehensive review of the immune profile in breast cancer patients.
• To elucidate the interplay between systemic and local immune reactions in tumor progression.
• To discuss the functional roles of innate and adaptive immune cells in breast cancer.

Main Methods:

• Comprehensive literature review of immuno-oncology and breast cancer research.
• Analysis of systemic and local immune responses in breast cancer.
• Discussion of the functional activity of immune cell populations.

Main Results:

• The immune system has a dual role in breast cancer, potentially promoting or inhibiting tumor growth.
• Tumor microenvironment and systemic immune responses are interconnected, influencing tumor progression.
• Specific immune cell populations contribute to either pro-tumor or anti-tumor immunity in BC.

Conclusions:

• Understanding the systemic immune profile in breast cancer is crucial.
• The interplay between local and systemic immunity offers insights into tumor progression.
• This review can guide the development of novel immunotherapies for breast cancer treatment.