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Updated: Jun 26, 2025
09:01
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
326
Nutritional modulation of antitumor immunity.
Mingeum Jeong1, Nicholas Collins2
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
Current Opinion in Immunology
|May 10, 2024
Summary
Dietary interventions like ketogenic, low-protein, high-fructose, and high-fiber diets can boost antitumor immunity. Integrating these nutritional strategies with immunotherapy may improve cancer treatment outcomes and long-term tumor control.
Area of Science:
- Immunology
- Oncology
- Nutritional Science
Background:
- Diet significantly influences immune system development and function.
- Understanding diet-immune interactions is crucial for developing novel cancer therapies.
Purpose of the Study:
- To review nutritional interventions that enhance antitumor immunity.
- To explore the potential of these diets in combination with immunotherapy for cancer treatment.
Main Methods:
- Literature review of studies on nutritional interventions and antitumor immunity.
- Analysis of specific diets: ketogenic, low-protein, high-fructose, high-fiber, and dietary restriction.
- Evaluation of the synergistic potential with immunotherapy protocols.
Main Results:
- Specific dietary patterns demonstrate the capacity to modulate immune responses against tumors.
- Ketogenic, low-protein, high-fructose, high-fiber diets, and dietary restriction are identified as promising interventions.
- Evidence suggests these diets can enhance the efficacy of immunotherapy.
Conclusions:
- Nutritional interventions represent a viable strategy to augment antitumor immunity.
- Combining defined diets with immunotherapy holds promise for improving therapeutic responsiveness and long-term tumor control in cancer patients.
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