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Association between Periodontitis and Hematologic Cancer: An NHIRD Cohort Study in Taiwan
Liang-Gie Huang1,2,3, Cheng-Chia Yu4, Ming-Ching Lin2
1School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.
Cancers
|May 11, 2024
Summary
This study found that male sex and hypertension increase the risk of hematologic cancers. Chronic periodontitis was also linked to specific blood cancer subtypes, highlighting the importance of managing this oral inflammatory condition.
Area of Science:
- Periodontology
- Oncology
- Epidemiology
Background:
- Chronic periodontitis is a global inflammatory condition linked to various cancers.
- Previous epidemiological studies have not established a clear association between chronic periodontitis and hematologic cancers in Taiwan.
Purpose of the Study:
- To investigate the association between chronic periodontitis and the incidence of hematologic cancers in Taiwan.
- To identify risk factors associated with hematologic malignancies in a large patient cohort.
Main Methods:
- Utilized the National Health Insurance Research Database (NHIRD) in Taiwan, including 601,628 patients diagnosed with chronic periodontitis (ICD-9-CM) from 2001-2021.
- Employed incidence density, Poisson regression for relative risk, and Kaplan-Meier analysis for cumulative incidence comparison.
- Conducted Cox proportional hazard regression to identify independent risk factors for hematologic cancers.
Main Results:
- A significantly lower cumulative incidence of hematologic cancer was observed in individuals without chronic periodontitis over a 12-year follow-up.
- Male sex (aHR = 1.21) and hypertension (aHR = 1.34) were significantly associated with an increased risk of hematologic cancers.
- Multivariate analysis indicated a higher risk for leukemia (aHR = 1.48) and a non-significant trend for lymphoma (aHR = 1.15) in relation to chronic periodontitis subtypes.
Conclusions:
- Male sex and hypertension are confirmed as significant risk factors for hematologic malignancies.
- The study confirms an association between chronic periodontitis and specific subtypes of hematologic cancers, underscoring the systemic implications of oral health.
