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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
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Lentigo Maligna Treatment-An Update.

Loredana Ungureanu1,2, Alina Florentina Vasilovici1,2, Ioana Irina Trufin3

  • 1Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

Journal of Clinical Medicine
|May 11, 2024
PubMed
Summary

Lentigo maligna (LM), a form of melanoma in situ, presents diagnostic and treatment challenges due to its slow growth and location. Effective management requires a multidisciplinary approach balancing recurrence risk and cosmetic outcomes.

Keywords:
imiquimodlentigo malignaradiotherapysurgerytreatment

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Area of Science:

  • Dermatology
  • Oncology
  • Medical Diagnostics

Background:

  • Lentigo maligna (LM) is a slow-growing melanoma in situ common in sun-damaged skin.
  • LM presents diagnostic and therapeutic challenges due to its mimicry of other lesions and location in sensitive areas.
  • Chronic UV exposure contributes to high mutation rates in LM.

Purpose of the Study:

  • To review diagnostic and therapeutic strategies for Lentigo Maligna (LM).
  • To highlight the challenges in managing LM and its progression to Lentigo Maligna Melanoma (LMM).
  • To emphasize the importance of a multidisciplinary approach for optimal patient outcomes.

Main Methods:

  • Integrated diagnostic approach using dermoscopy and reflectance confocal microscopy (RCM).
  • Evaluation of surgical treatments: Wide Local Excision (WLE) and Mohs Micrographic Surgery (MMS).
  • Assessment of non-surgical options: radiotherapy and imiquimod.

Main Results:

  • WLE faces challenges with subclinical extensions, increasing recurrence risk.
  • MMS offers precise margin control with cosmetic considerations for complex lesions.
  • Radiotherapy and imiquimod serve as viable alternatives for non-surgical candidates, with established efficacy and promising results, respectively.

Conclusions:

  • Accurate diagnosis and management of LM/LMM require integrating clinical assessment with advanced imaging (dermoscopy, RCM) and histology.
  • Treatment decisions must balance minimizing recurrence with preserving cosmetic integrity.
  • A multidisciplinary strategy is crucial for effective LM management and improved patient care.