[Effect of polysaccharides isolated from marine invertebrates on various functions of T- and B lymphocytes]

The effect of bioglycans from sea invertebrate on the level of the rosette forming cells (RFC) in the spleen, development of the delayed type hypersensitivity (DTH) induced by sheep red blood cells (SRBC) and the levels of hemagglutinins and hemolysins in the blood serum was studied in experimental animals. It was shown that the polysaccharides administered parenterally in a single dose had an effect on the humoral and cellular immunity. Under the effect of these preparations the level of the RFC in the spleen of the mice increased, with the increase of the RFC belonging to the lymphocyte T2- and B-subpopulations being more intensive. The use of the polysaccharides increased the mean geometric titers of serum antibodies. The polysaccharides administered at different periods with respect to the immunization and antigen challenge either decreased or increased the DTH induced by SRBC.