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Related Experiment Video

Updated: Jun 26, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Sodium Bicarbonate Decreases Alcohol Consumption in Mice.

Jason Lin¹, Ana P Rivadeneira¹, Yani Ye¹

¹Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.

International Journal of Molecular Sciences

|May 11, 2024

Summary

Raising blood pH in mice with sodium bicarbonate (NaHCO3) significantly reduced alcohol consumption and its reward value. This suggests systemic pH influences alcohol intake and motivation.

Keywords:

alcohol consumption alcohol drinking alcoholism pH sodium bicarbonate

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Area of Science:

Neuroscience
Physiology
Pharmacology

Background:

Neuronal pH levels influence alcohol reward and motivation.
Previous research indicated a link between low neuronal pH and increased alcohol consumption.

Purpose of the Study:

To investigate if systemic pH affects alcohol consumption in mice.
To determine if changes in systemic pH alter the reward value of alcohol.

Main Methods:

C57BL/6J mice were administered sodium bicarbonate (NaHCO3) to elevate blood pH.
Alcohol consumption was measured using drinking-in-the-dark and two-bottle free choice methods.
Alcohol reward was assessed via conditioned place preference, and taste sensitivity was evaluated.

Main Results:

Elevating blood pH with NaHCO3 led to a significant decrease in alcohol consumption, particularly at high concentrations (20%).
This effect was observed across different ages and in both male and female mice.
NaHCO3 administration reduced alcohol's reward value, as indicated by conditioned place preference, without affecting taste sensitivity to quinine or sucrose.

Conclusions:

Increasing systemic pH reduces alcohol consumption in mice.
The decrease in alcohol intake is attributed to a diminished reward value associated with alcohol when systemic pH is elevated.