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PhaseOne Hypochlorous Acid is Effective for Preventing Capsular Contracture and Infection in Primary Breast
Thomas Y Xia1, Amir Aminzada1, David Nguyen2
1Division of Plastic and Reconstructive Surgery, Saint Louis University and SSM Health, St. Louis, MO.
Aesthetic Surgery Journal
|May 13, 2026
Summary
Hypochlorous acid (HOCl) irrigation effectively prevents infection and capsular contracture in breast augmentation. This study found HOCl comparable to traditional methods, offering a safe and effective option for patients.
Area of Science:
- Plastic Surgery
- Surgical Infection Prevention
- Biocompatible Materials
Background:
- Breast pocket irrigation choice is debated.
- 0.025% hypochlorous acid (HOCl) shows promise for preventing infection and capsular contracture without cytotoxicity.
- This study evaluates HOCl in primary breast augmentation.
Purpose of the Study:
- Compare capsular contracture rates after primary breast augmentation using HOCl versus alternative irrigation solutions.
Main Methods:
- Retrospective review of primary breast augmentation patients (Jan 2018-Dec 2019).
- Comparison of four irrigation groups: HOCl, antibiotic with povidone iodine (PI), antibiotic alone, and chlorhexidine (CHG).
- Outcomes assessed: capsular contracture, mild infection, and severe infection.
Main Results:
- 0% capsular contracture for HOCl and CHG groups.
- Severe infection rates: 1.2% (HOCl), 0.4% (antibiotic with PI), 0% (antibiotic alone), 1.2% (CHG).
- Mild infection rates: 0% (HOCl), 0.5% (antibiotic with PI), 1.7% (antibiotic alone), 0% (CHG).
Conclusions:
- 0.025% HOCl is equally effective as standard techniques for preventing capsular contracture and infection in primary breast augmentation.
- HOCl demonstrates a favorable safety profile.
- HOCl represents a viable alternative for breast implant irrigation.
