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A 3D Organotypic Melanoma Spheroid Skin Model
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Development of Personalized Strategies for Precisely Battling Malignant Melanoma

Armond J Isaak1, GeGe R Clements1, Rand Gabriel M Buenaventura1

  • 1Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

International Journal of Molecular Sciences
|May 11, 2024
PubMed

Insights

Melanoma, a deadly skin cancer, presents treatment challenges due to resistance and toxicity. This review explores standard therapies and emerging personalized oncology strategies to overcome these barriers.

Area of Science:

  • Oncology
  • Dermatology
  • Genetics

Background:

  • Melanoma is a severe skin cancer with significant molecular heterogeneity.
  • Standard treatments like immune checkpoint inhibitors and targeted therapies are used for advanced melanoma.
  • Resistance and toxicity limit the effectiveness of current melanoma treatments.

Purpose of the Study:

  • To review the current landscape of standard melanoma therapies.
  • To explore personalized oncology techniques for melanoma treatment.
  • To summarize tools for overcoming barriers in melanoma management.

Main Methods:

  • Literature review of standard melanoma therapies.
  • Exploration of personalized oncology approaches.
  • Synthesis of current research on melanoma treatment strategies.

Main Results:

  • Standard therapies (immune checkpoint inhibitors, targeted therapies) have limitations.
  • Acquired resistance and toxicity are significant challenges.
  • Personalized oncology offers potential novel strategies.

Conclusions:

  • Novel strategies are needed to address resistance and toxicity in melanoma.
  • Personalized oncology holds promise for tailored melanoma treatment.
  • An updated understanding of available tools is crucial for effective melanoma management.
Keywords:
adoptive cell therapyimmunotherapiesmelanomametastatic treatmentpersonalized medicineprecision oncologytargeted therapyvaccine

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