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Updated: Jun 26, 2025

Optimization of Radiochemical Reactions using Droplet Arrays
Published on: February 12, 2021
Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid
Jeffrey Corsaut1,2, Elmer Soto1,2, Heather Biernaski1,2
1Lawson Health Research Institute, London, ON N6A 5W9, Canada.
Abstract:
Oxygen-15 (β+, t1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [15O]O2 over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.
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