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Addressing methodological concerns in omega-3 trial for bipolar disorder relapse prevention
Halliru Zailani1, Jane-Pei-Chen Chang2, Wei-Che Chiu3
1Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Nutrition, China Medical University, Taichung, Taiwan; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
None:
Our response addresses concerns raised about our pilot trial on omega-3 for bipolar disorder. We clarify randomization procedures, highlight the benefits of eicosapentaenoic-predominant formulations for a specific bipolar patients subgroup, and justify the use of Kaplan-Meier analysis despite limitations. We acknowledge analytical challenges due to strict inclusion criteria and encourage future research on specific bipolar subtypes and larger-scale trials for robust validation.
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