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What is the relationship between penile cancer and the microbiome? A scoping review
H A García-Perdomo1, V Granados-Duque2, P E Spiess3
1UROGIV Research Group, Universidad del Valle, Cali, Colombia; Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Cali, Colombia.
Introduction:
The microbiota is defined as the microorganisms in a particular environment. Conversely, the term microbiome is less firmly defined and is used to reference the habitat.
Objective:
To identify the association between the microbiome and the penile cancer EVIDENCE ACQUISITION: We performed this scoping review according to the recommendations of the Joanna Briggs Institute. We found five articles that fulfilled the inclusion criteria. We focused on oncogenesis and factors that alter the penile microbiome. We were not limited to language or setting. We searched MEDLINE (Ovid), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and LILACS from inception to the present day.
Evidence Synthesis:
We found nine studies describing multiple factors that could disturb the microbiome, such as sexual behavior, anatomic alterations including circumcision, and inflammatory factors: lichen sclerosus, poor genital hygiene, compromised immune system, smoking, and HPV infection.
Conclusion:
Overall, knowledge of the composition of the penile microbiota and its role in penile cancer oncogenesis is minimal.
Patient Summary:
Future studies should focus on the relationship between the microbiome and penile cancer to broaden this field of knowledge.
