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Updated: Aug 5, 2026
Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
Investigation of hematologic findings related to brucellosis in Anatolian region
Mehmet Çelik1, Yusuf Arslan1, Ertuğrul Topcu1
1From the Department of Infectious Diseases and Clinical Microbiology (Çelik, Ceylan); from the Department of Biostatistics (Erdoğdu), Faculty of Medicine, University of Harran; from the Department of Infectious Diseases and Clinical Microbiology (Yüksekkaya), Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, from the Department of Infectious Diseases and Clinical Microbiology (Arslan), Batman Training and Research Hospital, Batman, from the Department of Infectious Diseases and Clinical Microbiology (Topcu), Şırnak State Hospital, from the Department of Infectious Diseases and Clinical Microbiology (Altındağ, Atalay), Cizre Dr. Selahattin Cizrelioğlu State Hospital, Şırnak, from the Department of Infectious Diseases and Clinical Microbiology (Şahinoğlu), Manisa City Hospital, from the Department of Infectious Diseases and Clinical Microbiology (Özer), Faculty of Medicine, University of Manisa Celal Bayar, Manisa, from the Department of Infectious Diseases and Clinical Microbiology (Gürbüz), SBU Van Training and Research Hospital, Van, from the Department of Infectious Diseases and Clinical Microbiology (Demircan), Kahramanmaraş Necip Fazıl City Hospital, from the Department of Infectious Disease and Clinical Microbiology (Kuşçu), Faculty of Medicine, Sütcü Imam University, Kahramanmaraş, from the Department of Infectious Diseases and Clinical Microbiology (Emre), Kahta State Hospital, Adıyaman, from the Department of Infectious Diseases and Clinical Microbiology (Kırık), Elazığ Fethi Sekin City Hospital, Elazığ, from the Department of Infectious Diseases and Clinical Microbiology (Atasoy), Ankara City Hospital, Ankara, from the Department of Infectious Diseases and Clinical Microbiology (İpek), Mardin Training and Research Hospital, Mardin, from the Department of Infectious Diseases and Clinical Microbiology (Doğan), Bayburt State Hospital, Bayburt, from the Department of Infectious Disease and Clinical Microbiology (Atlı), SBU Gazi Yaşargil Training and Research Hospital, Diyarbakır, from the Department of Infectious Diseases and Clinical Microbiology (Alkan), Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, from the Department of Infectious Diseases and Clinical Microbiology (Çiçek), Bingol State Hospital, Bingol, from the Department of Infectious Diseases and Clinical Microbiology (Aldemir), Sivas Numune Hospital, Sivas, from the Department of Infectious Diseases and Clinical Microbiology (Şahin), Dr. Ersin Arslan Training and Research Hospital, from the Department of Infectious Diseases and Clinical Microbiology (Mızrakçı), Gaziantep LIV Hospital, Gaziantep, from the Department of Infectious Diseases and Clinical Microbiology (Ürkmez), Kırıkkale Yüksek İhtisas Hospital, Kırıkkale, from the Department of Infectious Disease and Clinical Microbiology (Al), Turhal State Hospital, Tokat, from the Department of Infectious Disease and Clinical Microbiology (Boran, Demiray), Bitlis State Hospital, Bitlis, and from the Department of Infectious Diseases and Clinical Microbiology (Tekin), Faculty of Medicine, University of Koç, Istanbul, Turkey.
Objectives:
To investigate the prevalence of hematologic findings and the relationship between hemogram parameters and brucellosis stages in patients.
Methods:
This multi-center study included patients older than 16 years of age who were followed up with a diagnosis of brucellosis. Patients' results, including white blood cell, hemoglobin, neutrophil, lymphocyte, monocyte, mean platelet volume, platelet and eosinophil counts were analyzed at the initial diagnosis.
Results:
In this study 51.3% of the patients diagnosed with brucellosis were male. The age median was 45 years for female and 41 years for male. A total of 55.1% of the patients had acute brucellosis, 28.2% had subacute, 7.4% had chronic and 9% had relapse. The most common hematologic findings in brucellosis patients were anemia (25.9%), monocytosis (15.9%), eosinopenia (10.3%), and leukocytosis (7.1%). Pancytopenia occurred in 0.8% of patients and was more prominent in the acute phase. The acute brucellosis group had lower white blood cell, hemoglobin, neutrophil, eosinophil, and platelet counts and mean platelet volume, and higher monocyte counts compared to subacute and chronic subgroups.
Conclusion:
It was noteworthy that in addition to anemia and monocytosis, eosinopenia was third most prominent laboratory findings in the study. Pancytopenia and thrombocytopenia rates were low.
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