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Updated: Jun 26, 2025

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Treatment of gastric varices with cyanoacrylate complicated by systemic embolization
Cristina Peixoto de Sousa1, Catarina Carvalho2, Célia Sousa3
1Department of Anesthesiology and Pain Therapy, Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE, Vila Real, Portugal.
Abstract:
Acute gastric variceal bleeding is a life-threatening condition that could be effectively treated with endoscopic cyanoacrylate injection diluted with lipiodol. The mixture acts as a tissue adhesive that polymerizes when in contact with blood in a gastric varix. This work reports a patient that presented to the emergency department with upper gastrointestinal bleeding due to acute variceal bleeding, who developed systemic embolization following cyanoacrylate injection therapy. This complication culminated in cerebral, splenic and renal infarctions with a fatal outcome. Systemic embolization is a very rare, but the most severe complication associated with endoscopic cyanoacrylate injection and should be considered in patients undergoing this treatment.
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