Advances in Microfluidic-Based Core@Shell Nanoparticles Fabrication for Cancer Applications

Area of Science:

• Nanotechnology
• Cancer Therapy
• Microfluidics

Background:

• Personalized cancer therapy increasingly relies on nanotechnology-based targeted drug delivery systems.
• Nanoparticles (NPs) offer controlled drug release, optimizing delivery to tumors and reducing side effects.
• Microfluidics (MFs) provide superior control over NP fabrication compared to conventional methods.

Purpose of the Study:

• To review the applications of microfluidics in producing core-shell nanoparticles (CSNPs) for cancer therapy.
• To discuss the versatility of microfluidic setups for controlled nanocarrier fabrication.
• To highlight advances in efficient and reproducible nanofabrication.

Main Methods:

• Compilation of current research on microfluidics for CSNP production.
• Analysis of various microchannel and micromixer configurations.
• Review of biological studies demonstrating effective drug delivery using microfluidically fabricated nanocarriers.

Main Results:

• Microfluidics allows precise control over CSNP size, structure, composition, and properties.
• Effective, safe, and controlled delivery of therapeutic agents like siRNA, pDNA, and cisplatin has been achieved.
• Continuous production and high reproducibility in nanocarrier fabrication are enabled by MFs.

Conclusions:

• Microfluidics is a powerful technology for developing advanced nanocarriers for cancer therapy.
• This technology facilitates innovative strategies in cancer nanofabrication with enhanced efficiency and control.
• Current technical, biological, and technological limitations need to be addressed for widespread adoption.