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Updated: Jun 26, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Iron-Catalyzed, Light-Driven Decarboxylative Alkoxyamination
Milan Innocent1, Clément Tanguy1, Sigrid Gavelle1
1Molecular, Macromolecular Chemistry and Materials, ESPCI Paris - PSL, CNRS, 10 rue Vauquelin, 75005, Paris, France.
Abstract:
An iron-catalyzed visible-light driven decarboxylative alkoxyamination is disclosed. In the presence of FeBr2 and TEMPO, a large array of carboxylic acids including marketed drugs and biobased molecules is turned into the corresponding alkoxyamine derivatives. The versatility of the latter offers an entry towards molecular diversity generation from abundant starting materials and catalyst. Overall, this method proposes a unified and general approach for LMCT-based iron-catalyzed decarboxylative functionalization.
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