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Related Concept Videos

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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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Edible Long-Afterglow Photoluminescent Materials for Bioimaging.

Shen Shen1, Qishan Xie1, Smruti Ranjan Sahoo2

  • 1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.

Advanced Materials (Deerfield Beach, Fla.)
|May 13, 2024
PubMed
Summary

Researchers developed edible, long-lasting afterglow materials for bioimaging. This novel doping strategy overcomes water quenching, enhancing afterglow quantum yield and lifetime for deep-tissue imaging applications.

Keywords:
bioimagingdoping materialslong‐afterglowphotoluminescencephotophysics

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Area of Science:

  • Materials Science
  • Biomedical Imaging
  • Photochemistry

Background:

  • Afterglow bioimaging often uses luminophores in hydrophilic matrices, but faces challenges with low quantum yield and short lifetimes.
  • Water's quenching effect and material biocompatibility present a dilemma for effective deep-tissue imaging.

Purpose of the Study:

  • To develop novel hydrophilic, water-insoluble organic-inorganic doping materials for enhanced afterglow bioimaging.
  • To overcome the limitations of existing afterglow materials, particularly concerning quantum yield, lifetime, and biocompatibility.

Main Methods:

  • An in situ metathesis promoted doping strategy was employed, mixing organic emitters with inorganic salts.
  • Metathesis reactions were used to synthesize water-insoluble, hydrophilic afterglow materials.
  • A barium meal formulation using coronene salt emitter and BaSO4 matrix was tested in animal models.

Main Results:

  • The strategy yielded edible long-afterglow photoluminescent materials with superior biocompatibility.
  • Phosphorescence quantum yield reached up to 66.24% with photoluminescent lifetimes of several seconds.
  • Successful in vivo imaging of the stomach in animal experiments was achieved through oral gavage, demonstrating deep tissue penetration.

Conclusions:

  • The developed materials offer excellent bioimaging effects, overcoming previous limitations.
  • The in situ metathesis doping strategy provides a flexible approach for creating advanced afterglow materials.
  • This advancement facilitates real-time probing and theranostic technologies in bioimaging.