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[Isolated primary vitreoretinal lymphoma (case report)].

A S Stoyukhina1, E N Korobov1, S A Smolin1

  • 1Krasnov Research Institute of Eye Diseases, Moscow, Russia.

Vestnik Oftalmologii
|May 13, 2024
PubMed
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This case report highlights primary intraocular lymphoma, often misdiagnosed as macular degeneration. Diagnostic imaging and genetic analysis confirmed vitreoretinal lymphoma, emphasizing accurate diagnosis for this rare condition.

Area of Science:

  • Ophthalmology
  • Oncology
  • Medical Diagnostics

Background:

  • Primary intraocular lymphoma (IOL) is a rare malignancy.
  • IOL can mimic other ocular conditions, leading to diagnostic delays.
  • Neovascular age-related macular degeneration (AMD) is a common differential diagnosis.

Purpose of the Study:

  • To present the diagnostic features of isolated primary intraocular lymphoma.
  • To illustrate the challenges in differentiating IOL from neovascular AMD.
  • To emphasize the role of advanced imaging and molecular diagnostics in IOL confirmation.

Main Methods:

  • Case report of a patient with suspected IOL.
  • Ocular examination including ultrasound, optical coherence tomography (OCT), and fundus autofluorescence (FAF).
Keywords:
MYD88 geneautofluorescenceintraocular lymphomaoptical coherence tomographyvitreoretinal lymphoma

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  • Molecular genetic analysis of vitreous samples: MYD88 gene mutation and immunoglobulin heavy chain (IGH) gene rearrangement for B-cell clonality.

    • Main Results:

    • Initial misdiagnosis as neovascular AMD.
    • Imaging revealed characteristic changes of vitreoretinal lymphoma.
    • Molecular analysis confirmed MYD88 mutation and B-cell clonality, confirming IOL diagnosis.

    Conclusions:

    • Isolated primary intraocular lymphoma can be challenging to diagnose.
    • Multimodal imaging is crucial for identifying subtle signs of IOL.
    • Molecular genetic testing provides definitive diagnosis for intraocular lymphoma.