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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: Jun 26, 2025

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
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In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

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Cancer therapy with antibodies.

Suman Paul1, Maximilian F Konig2, Drew M Pardoll3

  • 1Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. spaul19@jhmi.edu.

Nature Reviews. Cancer
|May 13, 2024
PubMed
Summary
This summary is machine-generated.

Therapeutic antibodies offer precise cancer cell targeting with minimal harm to healthy cells. This review details antibody-drug conjugates, immune checkpoint inhibitors, and bispecific antibodies for improved cancer treatment.

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Last Updated: Jun 26, 2025

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
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Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Cancer therapy faces challenges in selectively eliminating cancer cells while sparing normal tissues.
  • Targeted therapies, particularly antibodies, offer improved specificity and therapeutic index over conventional treatments.
  • Antibodies leverage high specificity to target antigens on cancer cells for therapeutic intervention.

Purpose of the Study:

  • To review diverse therapeutic antibody strategies for cancer treatment.
  • To elucidate the mechanisms of action, structural basis, and clinical applications of therapeutic antibodies.
  • To discuss ongoing research aimed at enhancing efficacy and reducing toxicity of antibody-based cancer therapies.

Main Methods:

  • Review of literature on therapeutic antibodies in cancer.
  • Analysis of antibody mechanisms including direct antagonism, antibody-drug conjugates (ADCs), immune checkpoint inhibition, and bispecific antibodies.
  • Discussion of structural aspects, clinical outcomes, and future research directions.

Main Results:

  • Therapeutic antibodies employ various mechanisms to eradicate cancer cells, including direct targeting, payload delivery via ADCs, T-cell activation through immune checkpoint inhibition, and T-cell redirection by bispecific antibodies.
  • Significant advancements have been made in antibody-based cancer therapies, leading to improved clinical outcomes.
  • Ongoing research focuses on optimizing antibody design for greater efficacy and reduced side effects.

Conclusions:

  • Therapeutic antibodies represent a powerful and evolving class of targeted cancer agents.
  • Different antibody formats and mechanisms offer versatile strategies for cancer treatment.
  • Continued innovation in antibody engineering and understanding of tumor immunology promises further advancements in oncology.