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Updated: Jun 26, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Catalytic asymmetric carbenoid α-C-H insertion of ether
Xin Li1, San-Hong Yue2, Zi-Yang Tan1
1Xiangya School of Pharmaceutical Sciences, Central South University Changsha 410013 China zhouyingjun@csu.edu.cn.
Abstract:
Significant advancements have been made in catalytic asymmetric α-C-H bond functionalization of ethers via carbenoid insertion over the past decade. Effective asymmetric catalytic systems, featuring a range of chiral metal catalysts, have been established for the enantioselective synthesis of diverse ether substrates. This has led to the generation of various enantioenriched, highly functionalized oxygen-containing structural motifs, facilitating their application in the asymmetric synthesis of bioactive natural products.
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